Pseudoephedrine

  • psi-Ephedrin
  • D-psi-Ephedrine
  • Psi-Ephedrine
  • trans-Ephedrine
  • Isoephedrine
  • D-Isoephedrine
Formula
C10H15NO
Structure
Description
Rhombic tablets from ether.
Uses
Medication.

Registry Numbers and Inventories.
CAS
90-82-4
EC (EINECS/ELINCS)
202-018-6
RTECS
UL5800000
RTECS class
Drug; Human Data
Beilstein/Gmelin
2414132
Beilstein Reference
4-13-00-01878
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed

Properties.
Formula
C10H15NO
Formula mass
165.26
Melting point, °C
58 - 59
Boiling point, °C
255
Vapor pressure, mmHg
0.009 (25 C)
Density
1.118 g/cm3
Solubility in water
Very soluble
pKa/pKb
4.62 (pKb)
Partition coefficient, pKow
1.05
Heat of fusion
32.0 kJ/mol
Heat of vaporization
52.0 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Not available.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Flash Point,°C
89
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Elevated blood pressure may occur, usually accompanied by rapid heart rate. Reduced body temperature and abnormally low blood pressure were reported in a case of a mixed drug overdose. anxiety, nervousness, insomnia, muscle tremor, seizures, and altered mental status may be noted. Drowsiness has been seen after overdose in children. Intracerebral hemorrhage has occurred. Hallucinations may occur, particularly in children. Coma has occurred in a mixed drug overdose. Pseudoephedrine is US FDA Pregnancy Category C. It is excreted in breast milk in low amounts.
   Ingestion
Anorexia, nausea, and vomiting are common. Ischemic colitis has been associated with therapeutic pseudoephedrine administration.
   Skin
Fixed drug eruptions, pseudo-scarlatina and systemic contact dermatitis have been reported.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.