Pyrithioxin

  • Dipyridoxolyldisulfide
  • Pyridoxine disulfide
  • Vitamin B6 disulfide
  • Bis(2-methyl-3-hydroxy-4-hydroxymethylpyridyl-5-methyl) disulfide
  • Bis[[5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridyl]methyl] disulfide
  • 3,3'-(Dithiobis(methylene))bis(5-hydroxy-6-methyl-4-pyridinemethanol
Formula
C16H20N2O4S2
Structure
Uses
A neurotropic agent which reduces permeability of blood-brain barrier to phosphate.

Registry Numbers and Inventories.
CAS
1098-97-1
EC (EINECS/ELINCS)
214-150-1
RTECS
UT4836666
RTECS class
Drug
Merck
12,8180
Beilstein/Gmelin
574678
Beilstein Reference
6-21
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C16H20N2O4S2
Formula mass
368.48
Melting point, °C
214 - 215
Vapor pressure, mmHg
4E-23 (25 C)
Solubility in water
Slightly soluble
pKa/pKb
5.42 (pKa)
Partition coefficient, pKow
1.69
Heat of vaporization
113.7 kJ/mol

Hazards and Protection.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.