p-Anisidine

  • 1-Amino-4-methoxybenzene
  • 4-Methoxyaniline
Formula
4-(CH3O)C6H4NH2
Structure
Description
White, fused crystalline solid, characteristic amine odor. May darken on exposure to light and air.
Uses
In the manufacture of azo dyes.

Registry Numbers and Inventories.
CAS
104-94-9
EC (EINECS/ELINCS)
203-254-2
EC Index Number
612-112-00-2
EC Class
Very toxic; Danger of cumulative effects; Dangerous for the Environment
R 26/27/28 33 50
S 28 36/37 45 61
RTECS
BZ5450000
RTECS class
Tumorigen; Drug; Mutagen
UN (DOT)
2431
Merck
13,670
Beilstein/Gmelin
471556
Beilstein Reference
4-13-00-01015
Swiss Giftliste 1
G-1044
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H9NO
Formula mass
123.16
Melting point, °C
55 - 58
Boiling point, °C
243
Vapor pressure, mmHg
0.03 (25 C)
Vapor density (air=1)
4.25
Evaporization number
Negligible at 20 C
Density
1.2 g/cm3 (20 C)
Solubility in water
Soluble
Viscosity
0.614 cp (20 C)
Surface tension
33.7 g/s2 (131 C)
Refractive index
1.5559 (60 C)
pKa/pKb
9.79 (pKb)
Partition coefficient, pKow
0.95
Heat of vaporization
34.3 kJ/mol
Heat of combustion
-3571 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
D1B
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Disposal code
9
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
105
Autoignition, °C
450
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. May polymerize explosively when involved in a fire. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Do NOT get water inside containers. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
This chemical is flammable.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OSHA PEL: TWA 0.5 mg/m3
Poison_Class
1*
Exposure effects
May cause cancer according to animal studies.
   Ingestion
May cause irritation of the digestive tract. May cause kidney damage. May cause methemoglobinemia, cyanosis, convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed.
   Inhalation
May cause severe allergic respiratory reaction. May cause respiratory tract irritation. Effects of inhalation may be delayed.
   Skin
May be absorbed through the skin in harmful amounts. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. If absorbed, may cause symptoms similar to those for ingestion. Effects of contact may be delayed. May cause contact dermatitis.
   Eyes
Causes severe eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Get medical aid if symptoms occur.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2431
Response guide
Hazard class
6.1
Packing Group
III
 
USCG CHRIS Code
ADP
 
HS Code
2922 22 00