p-Chlorophenol

  • 4-Hydroxychlorobenzene
  • 4-Chlorophenol
Formula
C6H5ClO
Structure
Description
Colorless or white crystals when pure, straw-colored or pink crystals when impure, unpleasant, penetrating, medicinal odor.
Uses
Chemical intermediate for the acaricide, ovex, rodenticide, phosacetin, pharmaceuticals, denaturant for alcohol, selective solvent in refining mineral oils.

Registry Numbers and Inventories.
CAS
106-48-9
EC (EINECS/ELINCS)
203-402-6
EC Index Number
604-008-00-0
EC Class
Harmful; Dangerous for the Environment
R 20/21/22 51/53
RTECS
SK2800000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
UN (DOT)
2020
Merck
13,2173
Beilstein/Gmelin
507004
Swiss Giftliste 1
G-180665
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H5ClO
Formula mass
128.56
Melting point, °C
41 - 44
Boiling point, °C
220
Vapor pressure, mmHg
0.078 (25 C)
Vapor density (air=1)
4.4
Saturation Concentration
0.013% (20 C) (calculated)
Odor Threshold Odor threshold 30 ppm
Critical temperature
441
Critical pressure
54.1
Density
1.31 g/cm3 (20 C)
Solubility in water
27 g/L
Viscosity
4.99 cp @ 50C
Surface tension
32.3 g/s2 (131 C)
Refractive index
1.5579 (40 C)
pKa/pKb
9.26 (pKa)
Partition coefficient, pKow
2.39
Heat of vaporization
47.5 kJ/mol
Heat of combustion
-2770 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Storage under a nitrogen blanket has been recommended. Store protected from moisture.
Handling
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. Discard contaminated shoes.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear natural rubber gloves, apron, and/or clothing. Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear natural rubber gloves, apron, and/or clothing. Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Disposal code
3
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Moisture, active metals, strong oxidizing agents, acid anhydrides, acid chlorides.
Decomposition
Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
116
Upper exp. limit, %
8.8
Lower exp. limit, %
1.7
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. May polymerize explosively when involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Combustible material; may burn but does not ignite readily. Extinguishing media: Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
Combustible when exposed to heat or flame
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Toxic and irritating hydrogen chloride and chlorine gases may form in fires.
Health
4
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OEL-RUSSIA:STEL 1 mg/m3;Skin
Carcinogin
I-2B
Poison_Class
3
Exposure effects
May cause liver and kidney damage. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death. Effects may be delayed. Reproductive effects have been reported in animals.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed. Overexposure may cause methemoglobinemia. May cause pallor, loss of appetite, nausea, vomiting, diarrhea, weakness, darkened urine, headache, sweating, convulsions, cyanosis, unconsciousness, respiratory failure and death. May cause burning sensation in lips, mouth, and throat and feeling of constriction or pain in throat or chest. Tingling or pain in hands may also occur.
   Inhalation
Causes respiratory tract irritation. May cause liver and kidney damage. May cause effects similar to those described for ingestion. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown blood. Inhalation can cause systemic acidosis and methemoglobinemia. Can produce delayed pulmonary edema.
   Skin
Causes severe skin irritation. May be absorbed through the skin. Contact with the skin may cause staining, inflammation, and thickening of the skin.
   Eyes
Causes severe eye irritation. May cause chemical conjunctivitis.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes.
   Eyes
Get medical aid. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
2020
Response guide
Hazard class
6.1
Packing Group
III
 
USCG CHRIS Code
CPN
 
HS Code
2908 10 00
 
Std. Transport #
4925174