p-Cresol

  • 4-Hydroxy-1-methylbenzene
  • 4-Methylphenol
  • p-Hydroxytoluene
Formula
C7H8O
Structure
Description
Colorless crystals or yellowish liquid, with a phenolic or sweet, tarry odor.
Uses
Chemical intermediate for tricresyl phosphate & cresyl diphenyl phosphate, agent in prodn of disinfectants, explosives, & synthetic perfumery materials, metal cleaning agent, solvent for wire enamels, agent in ore flotation, monomer for phenolic resins.

Registry Numbers and Inventories.
CAS
106-44-5
EC (EINECS/ELINCS)
203-398-6
EC Index Number
604-004-00-9
EC Class
Toxic; Corrosive
R 24/25 34
S 36/37/39 45
RTECS
GO6475000
RTECS class
Tumorigen; Drug; Mutagen; Natural Product; Primary Irritant
UN (DOT)
2076
Merck
13,2604
Beilstein/Gmelin
1305151
Beilstein Reference
4-06-00-02093
RCRA
U052
Swiss Giftliste 1
G-5879
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H8O
Formula mass
108.14
Melting point, °C
32 - 34
Boiling point, °C
201.8
Vapor pressure, mmHg
0.1
Saturation Concentration
145 ppm (0.015%) at 25 C (calculated)
Odor Threshold Odor threshold 0.46 ppb
Critical temperature
431.4
Critical pressure
50.8
Density
1.034 g/cm3 (20 C)
Solubility in water
19 g/L
Viscosity
7.0 cp at 40C
Surface tension
41.8 g/s2
Refractive index
1.5312 (20 C)
pKa/pKb
10.26 (pKa)
Partition coefficient, pKow
1.94
Heat of fusion
11.9 kJ/mol
Heat of vaporization
47.45 kJ/mol
Heat of combustion
-3773 kJ/mol

Hazards and Protection.
Storage
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
D1A E
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not ingest or inhale. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Provide ventilation.
Disposal code
9
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Oxidizing agents, strong acids, coatings, plastics, rubber, alliphatic amines, amides (e.g. butyramide, diethyltoluamide, dimethyl formamide), chlorosulfonic acid, oleum, alkalies.
Decomposition
Carbon monoxide, carbon dioxide, cresol.

Fire.
Flash Point,°C
86
Autoignition, °C
555
Upper exp. limit, %
7.6
Lower exp. limit, %
1.1
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. May polymerize explosively when involved in a fire. Extinguishing media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam.
Fire potential
Slightly flammable. With flame. If handled at elevated temperatures, flammable toxic vapors may be given off.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Emits highly toxic fumes.
Health
3
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OSHA PEL: TWA 5 ppm (22 mg/m3) skin NIOSH REL: TWA 2.3 ppm (10 mg/m3) NIOSH IDLH: 250 ppm
Poison_Class
3
Exposure effects
Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion.
   Ingestion
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. Causes severe digestive tract burns with abdominal pain, vomiting, and possible death. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal.
   Inhalation
Irritation may lead to chemical pneumonitis and pulmonary edema. May cause liver and kidney damage. May cause severe irritation of the upper respiratory tract with pain, burns, and inflammation. Causes chemical burns to the respiratory tract.
   Skin
Causes skin burns. May be absorbed through the skin in harmful amounts.
   Eyes
Causes eye burns. May result in corneal injury. Contact with liquid is corrosive to the eyes and causes severe burns.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
2076
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
CSO
 
21 Phenols, Cresols
HS Code
2907 12 00
 
IMO Pollution Category
A
IMO Hazard code
S/P