p-Nitrochlorobenzene

  • 4-Chloronitrobenzene
  • p-Chloronitrobenzene
  • 1-Chloro-4-nitrobenzene
Formula
C6H4ClNO2
Structure
Description
Light yellow crystalline solid. Sweet odor.
Uses
p-Chloronitrobenzene is used to manufacture p-nitrophenol, p-nitroaniline, p-aminophenol, phenacetin, acetominophen, parathion and other agricultural chemicals, rubber chemicals, antioxidants, oil additives and dapsone (an antimalarial drug).

Registry Numbers and Inventories.
CAS
100-00-5
EC (EINECS/ELINCS)
202-809-6
EC Index Number
610-005-00-5
EC Class
Toxic; Danger of cumulative effects; Dangerous for the Environment
R 23/24/25 33 51/53
S 28 36/37 45 61
RTECS
CZ1050000
RTECS class
Tumorigen; Mutagen; Reproductive Effector
UN (DOT)
1578
Merck
13,2170
Beilstein/Gmelin
508691
Beilstein Reference
4-05-00-00723
Swiss Giftliste 1
G-2641
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H4ClNO2
Formula mass
157.56
Melting point, °C
83
Boiling point, °C
239
Vapor pressure, mmHg
0.09 (25 C)
Vapor density (air=1)
5.44
Critical temperature
478
Critical pressure
3928
Density
1.52 g/cm3 (20 C)
Solubility in water
0.21 g/L (20 C)
Viscosity
1.07x10-3 pa-s @ 356.65 deg K
Surface tension
34.3 g/s2 (90 C)
Refractive index
1.5376 (100 C)
Partition coefficient, pKow
2.39
Heat of vaporization
62.1 kJ/mol
Heat of combustion
-2909 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with skin and eyes. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Disposal code
9
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
95
Autoignition, °C
515
Upper exp. limit, %
8.8
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Containers may explode when heated. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
This compound is combustible.
Hazards
Containers may explode when heated.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
3
 

Health.
Exposure limit(s)
TLV: 0.1 ppm; 0.64 mg/m3 (as TWA) A3 (skin) (ACGIH 1997). OSHA PEL: TWA 1 mg/m3 skin NIOSH REL: Ca See Appendix A skin NIOSH IDLH: Potential occupational carcinogen 100 mg/m3
Carcinogin
G-A3, CP65
Poison_Class
4
Exposure effects
May cause liver and kidney damage. Absorption into the body leads to the formation of methemoglobin which in sufficient concentrations causes cyanosis. May cause anemia and other blood cell abnormalities. May cause fatigue, dizziness, headache, insomnia and weight loss.
   Ingestion
Harmful if swallowed. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May cause central nervous system depression.
   Inhalation
May cause effects similar to those described for ingestion. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown blood.
   Skin
Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1578
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
CNP
 
HS Code
2904 90 85