p-Thiocresol

  • Toluene-4-thiol
  • 2-Methylthiophenol
  • o-Toluenethiol
  • 2-Methylbenzenethiol
Formula
4-(CH3)C6H4SH
Structure
Description
White, solid, leaflets, also cream to white, moist crystals, musty odor.
Uses
Antiseptic, dermatologic unspecified isomer.

Registry Numbers and Inventories.
CAS
106-45-6
EC (EINECS/ELINCS)
203-399-1
EC Class
irritant
R 20/21/22 36/38
S 28 36/37 45
RTECS
XT8925000
RTECS class
Other
UN (DOT)
2811
Merck
12,9461
Beilstein/Gmelin
605761
Beilstein Reference
4-06-00-02153
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C7H8S
Formula mass
124.21
Melting point, °C
39 - 42
Boiling point, °C
195
Vapor pressure, mmHg
0.6 (25 C)
Odor Threshold Odor threshold 1.0X10-4 mg/L
Density
1.0220 g/cm3 (51C)
Solubility in water
Insoluble
Surface tension
33.84 g/s2 (51 C)
pKa/pKb
6.82 (pKa)
Partition coefficient, pKow
2.98
Heat of vaporization
41.4 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
B3
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Disposal code
9
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents
Decomposition
Carbon monoxide, oxides of sulfur, carbon dioxide, hydrogen sulfide.

Fire.
Flash Point,°C
68
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode when heated. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Use agent most appropriate to extinguish fire.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
When heated to decomp, it emits toxic fumes of sulfur oxides.

Health.
Exposure effects
Abnormally low blood pressure, reduced body temperature, rapid breathing, and rapid heart rate may develop with severe toxicity. Initial CNS excitation, including seizures, is commonly followed by CNS depression ranging from lethargy to coma and death. Fetotoxicity and skeletal abnormalities have been reported in animal experiments.
   Ingestion
The toxicological properties of this substance have not been fully investigated. Causes gastrointestinal tract irritation.
   Inhalation
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
   Skin
Causes skin irritation. The toxicological properties of this material have not been fully investigated.
   Eyes
Causes eye irritation. The toxicological properties of this material have not been fully investigated.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
HS Code
2930 90 70