p-Toluenesulfonyl chloride

  • 4Methylbenzenesulfonyl chloride
  • p-Tolylsulfonyl chloride
  • p-Tosyl chloride
Formula
4-(CH3)C6H4SO2Cl
Structure
Description
A white to gray powdered solid with a distinctive odor.
Uses
Organic synthesis.

Registry Numbers and Inventories.
CAS
98-59-9
EC (EINECS/ELINCS)
202-684-8
EC Class
corrosive
R 34 37
S 26 28 36/37/39 45
UN (DOT)
1759
Merck
12,9672
Beilstein/Gmelin
607898
Beilstein Reference
4-11-00-00375
Swiss Giftliste 1
G-2955
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H7ClO2S
Formula mass
190.65
Melting point, °C
67
Boiling point, °C
265
Vapor pressure, mmHg
0.015 (25 C)
Vapor density (air=1)
1.33
Density
1.49 g/cm3
Solubility in water
Insoluble
Surface tension
31.82 g/s2 (103.5 C)
Partition coefficient, pKow
2.45
Heat of vaporization
48.3 kJ/mol

Hazards and Protection.
Storage
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Corrosives area. Do not store in metal containers.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal.
Disposal code
11
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizers. Water hydrolyzes material liberating acidic gas which in contact with metal surfaces can generate flammable and/or explosive hydrogen gas.
Decomposition
Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, sulfur oxides (SOx), including sulfur oxide and sulfur dioxide.

Fire.
Flash Point,°C
114
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Do NOT use water directly on fire. Use carbon dioxide or dry chemical.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Poison_Class
2
Exposure effects
   Ingestion
Causes gastrointestinal tract burns.
   Inhalation
May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Causes chemical burns to the respiratory tract.
   Skin
Contact with skin causes irritation and possible burns, especially if the skin is wet or moist. Vesicant.
   Eyes
May cause eye injury. Lachrymator. Causes eye irritation and burns.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1759
Response guide
Hazard class
8
Packing Group
I; II; III
 
HS Code
2904 90 20
 
Std. Transport #
4936013