- Tosyl isocyanate
- Benzenesulfonyl isocyanate, 4-methyl
Clear, colorless liquid.
Registry Numbers and Inventories.
EC Index Number
Reacts violently with water; Irritant; Sensitising
R 14 36/37/38 42
S 23 26 36/37/39
Swiss Giftliste 1
Japan ENCS (MITI)
Melting point, °C
Boiling point, °C
Vapor pressure, mmHg
0.004 (25 C)
Vapor density (air=1)
1.295 g/cm3 (20 C)
Solubility in water
1.53 (20 C)
Partition coefficient, pKow
Heat of vaporization
Hazards and Protection.
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water.
Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not allow water to get into the container because of violent reaction. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Do not allow contact with water. Keep from contact with moist air and steam.
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation. Do not expose spill to water.
Stable under normal temperatures and pressures. Combines vigorously or explosively with water.
Water, alcohols, amines, acids, strong bases, strong oxidizing agents.
Hydrogen cyanide, nitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. May ignite or explode on contact with steam or moist air. Extinguishing media: Use dry sand or earth to smother fire. Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER! Contact professional fire-fighters immediately.
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
Vapors form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff.
Fire will produce irritating, corrosive and/or toxic gases.
Effects may be delayed.
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Causes respiratory tract irritation. Can produce delayed pulmonary edema. May cause respiratory sensitization.
May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Contact with skin causes irritation and possible burns, especially if the skin is wet or moist.
Causes eye irritation. Lachrymator. When substances becomes wet or comes in contact with moisture of the mucous membranes, it becomes an irritant. May cause chemical conjunctivitis.
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. If water-reactive products are embedded in the skin, no water should be applied. The embedded products should be covered with a light oil.
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.