p-Toluenesulfonyl isocyanate

  • Tosyl isocyanate
  • 4-Isocyanatosulphonyltoluene
  • Benzenesulfonyl isocyanate, 4-methyl
Formula
C8H7NO3S
Structure
Description
Clear, colorless liquid.

Registry Numbers and Inventories.
CAS
4083-64-1
EC (EINECS/ELINCS)
223-810-8
EC Index Number
615-012-00-7
EC Class
Reacts violently with water; Irritant; Sensitising
R 14 36/37/38 42
S 23 26 36/37/39
RTECS
DB9032000
RTECS class
Primary Irritant
UN (DOT)
2206
Beilstein/Gmelin
391287
Beilstein Reference
4-11-00-00402
Swiss Giftliste 1
G-10061
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C8H7NO3S
Formula mass
197.22
Melting point, °C
5
Boiling point, °C
288
Vapor pressure, mmHg
0.004 (25 C)
Vapor density (air=1)
6.80
Density
1.295 g/cm3 (20 C)
Solubility in water
Insoluble
Refractive index
1.53 (20 C)
Partition coefficient, pKow
2.44
Heat of vaporization
50.7 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water.
Handling
Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not allow water to get into the container because of violent reaction. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Do not allow contact with water. Keep from contact with moist air and steam.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation. Do not expose spill to water.
Stability
Stable under normal temperatures and pressures. Combines vigorously or explosively with water.
Incompatibilities
Water, alcohols, amines, acids, strong bases, strong oxidizing agents.
Decomposition
Hydrogen cyanide, nitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
128
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. May ignite or explode on contact with steam or moist air. Extinguishing media: Use dry sand or earth to smother fire. Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER! Contact professional fire-fighters immediately.
Fire potential
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
Hazards
Vapors form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
1
 
 
Reactivity
2
 

Health.
Poison_Class
2
Exposure effects
Effects may be delayed.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
Causes respiratory tract irritation. Can produce delayed pulmonary edema. May cause respiratory sensitization.
   Skin
May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Contact with skin causes irritation and possible burns, especially if the skin is wet or moist.
   Eyes
Causes eye irritation. Lachrymator. When substances becomes wet or comes in contact with moisture of the mucous membranes, it becomes an irritant. May cause chemical conjunctivitis.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. If water-reactive products are embedded in the skin, no water should be applied. The embedded products should be covered with a light oil.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.

Transport.
UN number
2206
Response guide
Hazard class
6.1
Packing Group
II; III