p-Toluidine

  • p-Methylaniline
  • 4-Aminotoluene
  • 4-Amino-1-methylbenzene
Formula
CH3C6H4NH2
Structure
Description
Colorless solid. May be absorbed through the skin.
Uses
Dyes, organic synthesis, reagent for lignin, nitrite, chloroglucinol.

Registry Numbers and Inventories.
CAS
106-49-0
EC (EINECS/ELINCS)
203-403-1
EC Index Number
612-160-00-4
EC Class
Carcinogenic Category 3; Toxic; Irritant; Sensitising; Dangerous for the Environment
R 23/24/25 36 40 43 50
S 28 36/37 45 61
RTECS
XU3150000
RTECS class
Mutagen; Primary Irritant
UN (DOT)
1708
Merck
12,9674
Beilstein/Gmelin
471281
Beilstein Reference
4-12-00-01866
RCRA
U353
Swiss Giftliste 1
G-3208
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H9N
Formula mass
107.16
Melting point, °C
43
Boiling point, °C
201
Vapor pressure, mmHg
1-.38 (25 C)
Vapor density (air=1)
3.9
Critical temperature
394
Critical pressure
22.7
Density
1.046 g/cm3 (20 C)
Solubility in water
7 g/L
Viscosity
1.8 cp (50 C)
Surface tension
34.6 g/s2
Refractive index
1.5534 (45 C)
pKa/pKb
8.9 (pKb6)
Partition coefficient, pKow
1.40
Heat of fusion
17.9 kJ/mol
Heat of vaporization
43.4 kJ/mol
Heat of combustion
-2954 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked.
Handling
Wash thoroughly after handling. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Remove all sources of ignition.
Disposal code
9
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Aromatic amines, strong acids, oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
87
Autoignition, °C
482
Upper exp. limit, %
7.6
Lower exp. limit, %
1.2
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Combustible solid. May react with metals and lead to the formation of flammable hydrogen gas. Containers may explode when heated. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
Flammable when exposed to heat, flame, or oxidizers.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Toxic and flammable vapors may form in fire.
Health
3
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
NIOSH REL: Ca See Appendix A
Poison_Class
1*
Exposure effects
Chronic inhalation may cause effects similar to those of acute inhalation. May cause cancer in humans. Chronic exposure leads to anemia, anorexia, weight loss, and cutaneous lesions.
   Ingestion
May cause irritation of the digestive tract. May be harmful if swallowed.
   Inhalation
May be fatal if inhaled. May cause drowsiness, unconsciousness, and central nervous system depression. Inhalation causes anoxia due to the formation of methemoglobin and hematuria. Inhalation may lead to dizziness, weakness, and drowsiness, leading to stupor, unconsciousness, and even death. Inhalation may produce headache and cyanosis of the lips, the mucous membranes, and the fingernail beds, and the tongue.
   Skin
Causes skin irritation. Harmful if absorbed through the skin.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1708
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
TOD
 
9 Aromatic amines
HS Code
3822 00 00
 
Std. Transport #
4913176