p-Tolyl isocyanate

  • 1-Isocyanato-4-methylbenzene
  • p-Isocyanatotoluene
  • 4-Isocyanatotoluene
  • 4-Methylphenyl isocyanate
  • p-Methylphenyl isocyanate
  • Isocyanic acid, p-tolyl ester
Formula
C8H7NO
Structure
Description
Light brown liquid.

Registry Numbers and Inventories.
CAS
622-58-2
EC (EINECS/ELINCS)
210-743-4
R 23 22 36/37/38 42
S 23 26 36/37/39 45
RTECS
DA3681666
RTECS class
Other
UN (DOT)
2206
Beilstein/Gmelin
4094771
Canada DSL/NDSL
DSL
US TSCA
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C8H7NO
Formula mass
133.15
Boiling point, °C
193 - 195
Vapor pressure, mmHg
0.54 (25 C)
Critical temperature
429
Critical pressure
34.4
Density
1.056 g/cm3 (20 C)
Solubility in water
Insoluble
Refractive index
1.5313 (20 C)
Partition coefficient, pKow
3.04
Heat of vaporization
42.7 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
64
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
Hazards
Vapors form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Animals exposed to 0.48 mg/l, the lowest dose tested, died in sixteen days.
   Skin
May cause skin irritation. The toxicological properties of this material have not been fully investigated.
   Eyes
May cause eye irritation. The toxicological properties of this material have not been fully investigated.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2206
Response guide
Hazard class
6.1
Packing Group
II; III