Quinacrine

  • Malaricida
  • Acrinamine
  • Mepacrine
  • Akrichin
  • 3-Chloro-9-(4'-diethylamino-1'-methylbutylamino)-7-methoxyacridine
  • 1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-
Formula
C23H30ClN3O
Structure
Description
Bright yellow crystalline powder.
Uses
Medication (vet).

Registry Numbers and Inventories.
CAS
69-05-6
EC (EINECS/ELINCS)
200-700-8
RTECS
AR7700000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,8225
Beilstein/Gmelin
4834013
Beilstein Reference
5-22-12-00235
Austrailia AICS
Listed

Properties.
Formula
C23H30ClN3O*2ClH
Formula mass
399.96
Melting point, °C
248
Decomposition point, °C
248
Density
1.28 g/cm3
Solubility in water
1g in 36 ml

Hazards and Protection.
Storage
Store below 40C, preferably between 15 and 30C in a light-resistant container, unless otherwise specified by manufacturer. Store in a tight container.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Following severe exposures, coma and seizures may occur. With therapeutic use - mild to moderate cinchonism may cause headache, lethargy, agitation, memory impairment, delirium, and hallucinations.
   Ingestion
The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.
   Inhalation
The toxicological properties of this substance have not been fully investigated. Inhalation of dust may cause respiratory tract irritation.
   Skin
No information regarding skin irritation and other potential effects was found.
   Eyes
Dust may cause mechanical irritation. No information regarding eye irritation and other potential effects was found.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.