Quinestrol

  • Ethynylestradiol-3-cyclopentyl ether
  • 3-Cyclopentyloxy-17a-ethynyl-1,3,5(10)-estratrien-17-ol
  • 3-(Cyclopentyloxy)-19-nor-17a-pregna-1,3,5(10)-trien-20-yn-17-ol
  • 19-Nor-17a-pregna-1,3,5(10)-trien-20-yn-17-ol, 3-(cyclopentyloxy)-
  • 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-cyclopentyl ether
  • 17a-Ethynylestradiol 3-cyclopentyl ether17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-cyclopentyl ether
Formula
C25H32O2
Structure
Uses
Used to treat symptoms of menopause, such as hot flashes. Also used to treat breast and prostate cancer

Registry Numbers and Inventories.
CAS
152-43-2
EC (EINECS/ELINCS)
205-803-1
45 61 20/21/22
53 22 36/37/39 45
RTECS
RC8948000
RTECS class
Drug; Reproductive Effector; Human Data; Hormone
Merck
12,8239
Beilstein/Gmelin
2013312
Beilstein Reference
5-06

Properties.
Formula
C25H32O2
Formula mass
364.53
Melting point, °C
107 - 108
Vapor pressure, mmHg
6E-11 (25 C)
Solubility in water
Insoluble
pKa/pKb
13.10 (pKa)
Partition coefficient, pKow
5.40
Heat of vaporization
81.3 kJ/mol

Hazards and Protection.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide.

Fire.
Flash Point,°C
219
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Toxic. May cause cancer. Harmful by inhalation, in contact with skin and if swallowed. May cause harm to the unborn child. Reproductive hazard. Target organ(s): Liver. Blood.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.