Quinidine sulfate

  • Cinchonan-9-ol, 6'-methoxy-(9s)-sulfate (2:1) (salt)
  • Cin-quin
  • 6'-Methoxycinchonan-9-ol sulfate
  • Quinicardine
  • Quinidate
Formula
(C20H24N2O2)2.H2O4S
Structure
Description
Occurs as fine, needle-like, white crystals which frequently cohere in
Uses
Medication.

Registry Numbers and Inventories.
CAS
50-54-4
EC (EINECS/ELINCS)
200-046-3
RTECS
VA5950000
RTECS class
Drug; Human Data
Beilstein/Gmelin
3582804
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
2C20H24N2O2*H2O4S
Formula mass
747.00
Solubility in water
slightly soluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Protect from light; darkens on exposure to light dihydrate quinidine gluconate, quinidine polygalacturonate, and quinidine sulfate darken on exposure to light and should be stored in well closed, light-resistant containers. Solutions of quinidine salts slowly acquire a brownish tint on exposure to light. Only colorless, clear solutions of quinidine gluconate injection should be used. Quinidine gluconate injection should be stored at 15-30 C. When diluted to a concentration of 16 mgml with 5% dextrose injection, quinidine gluconate injection is stable for 24 hr at room temperature and up to 48 hr when refrigerated. Quindine salts.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Following severe exposures, coma and seizures may occur. With therapeutic use - mild to moderate cinchonism may cause headache, lethargy, agitation, memory impairment, delirium, and hallucinations.
   Inhalation
Respiratory depression and pulmonary edema may occur.
   Skin
Therapeutic use of quinidine has been associated with angioedema, lichen planus, photodermatitis, urticaria, morbilliform eruptions, and erythema multiforme.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.