Quinidine

  • Cinchonan-9-ol, 6'-methoxy-(95)
  • Conchinin
  • a-(6-Methoxy-4-quinolyl)-5-Vinyl-2-quinuclidinemethanol
  • 6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol
  • Pitayine
  • (8R,9S)-Quinidine
Formula
C20H24N2O2
Structure
Description
Crystals or white powder.
Uses
Medication.

Registry Numbers and Inventories.
CAS
56-54-2
EC (EINECS/ELINCS)
200-279-0
S 22 36/37
RTECS
VA4725000
RTECS class
Drug; Primary Irritant
Merck
12,8244
Beilstein/Gmelin
91866
Beilstein Reference
5-23-13-00395
Swiss Giftliste 1
G-7948
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C20H24N2O2
Formula mass
324.42
Melting point, °C
174-175
Solubility in water
Insoluble
pKa/pKb
4.87 (pKb)
Partition coefficient, pKow
2.88

Hazards and Protection.
Storage
Keep containers tightly closed. Store protected from light. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Do not ingest or inhale. Use only in a chemical fume hood. Do not breathe dust.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Provide ventilation.
Stability
Stable under normal temperatures and pressures. Darkens on exposure to light.
Incompatibilities
Strong oxidizing agents, direct light.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use carbon dioxide, dry chemical powder or water spray.
Fire potential
This material is probably combustible.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Poison_Class
3
Exposure effects
Chronic exposure may cause blood effects. Repeated exposure may cause stomach pains, vomiting, and diarrhea. Pe ople with preexisting heart conditions, asthma, muscle weakness, kidne y or liver insufficiencies, infection or fever should avoid quinidine.
   Ingestion
Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause cardiac effects such as heart blocks, arrhythmias, shock and possible death due to cardiovascular collapse. May result in severe disturbances of cardiac conduction and hypotension accompanied by central nervous system toxicity. May cause decreased kidney function resulting in severe intoxication. In patients with preexisting cardiovascular disease, pulmonary edema may occur.
   Inhalation
May cause respiratory tract irritation.
   Skin
Causes mild skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Induce vomiting only when instructed to do so by a physician.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.