Quinine

  • Chinine
  • 6'-Methoxycinchonidine
  • Cinchonan-9-ol, 6'-methoxy-, (8a,9R)-
Formula
C20H24N2O2
Structure
Description
Triboluminescent, orthorhombic needles from absolute alcohol. Odorless.
Uses
Medication.

Registry Numbers and Inventories.
CAS
130-95-0
EC (EINECS/ELINCS)
205-003-2
R 22 42/43
S 22 36/37 45
RTECS
VA6020000
RTECS class
Mutagen; Reproductive Effector; Human Data
UN (DOT)
3335
Merck
12,8245
Beilstein/Gmelin
91867
Beilstein Reference
5-23-13-00395
Swiss Giftliste 1
G-1373
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C20H24N2O2
Formula mass
324.43
Melting point, °C
176
Solubility in water
Slightly soluble
Refractive index
1.625 (15 C)
pKa/pKb
4.87 (pKb)

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40C.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions.
Disposal code
3
Stability
Stable under normal temperatures and pressures. May discolor on exposure to light.
Incompatibilities
Strong oxidizing agents - light.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use agent most appropriate to extinguish fire.
Fire potential
Slightly flammable.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Poison_Class
3
Exposure effects
Chronic ingestion may cause effects similar to those of acute ingestion.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Ingestion may produce visual and hearing disturbances. Human systemic effects by ingestion may include: visual field changes, tinnitus, and nausea or vomiting.
   Inhalation
May cause respiratory tract irritation.
   Skin
Causes skin irritation. May cause allergic contact dermatitis.
   Eyes
Causes eye irritation. Contact with the eyes causes eyes to become swollen, watery, and exude a sticky viscous liquid which forms yellowish crusts. Causes visual disturbances including: blurred vision, disturbed color perception, photophobia, diplopia, night blindness, constricted visual fields, mydriasis, and possibly blindness.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
3335
Response guide
HS Code
2939 21 10