- 1,4-Dimercapto-2,3-butanediol, (2R,3R)-rel-
- Cleland's reagent
Solid. Disagreeable odor.
Used to reduce disulfide bonds quantitatively and maintain monothiols in the reduced state. At low concentrations, DTT stabilizes enzymes and other proteins which possess free sulfhydryl groups and has been shown to restore activity lost by oxidation of these groups in vitro.
Registry Numbers and Inventories.
Melting point, °C
40 - 43
Boiling point, °C
125 - 130 (2 torr)
Solubility in water
Hazards and Protection.
Store in a cool, dry place. Store in a tightly closed container.
Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions.
Stable under normal temperatures and pressures.
Carbon monoxide, oxides of sulfur, carbon dioxide.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. Extinguishing media: Use water spray, dry chemical, or carbon dioxide.
The toxicological properties of this substance have not been fully investigated. Organic sulfur compounds may cause headache, nausea, vomiting, and incoordination. Respiratory and muscular paralysis, kidney and liver abnormalities have also been reported.
The toxicological properties of this substance have not been fully investigated.
No information regarding skin irritation and other potential effects was found.
No information regarding eye irritation and other potential effects was found.
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
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