Ramatroban

  • 3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid
  • 9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (R)-
Formula
C21H21FN2O4S
Structure
Description
Crystalline solid.

Registry Numbers and Inventories.
CAS
116649-85-5
Merck
12,10455

Properties.
Formula
C21H21FN2O4S
Formula mass
416.47
Vapor pressure, mmHg
4.9E-18 (25 C)
Density
1.43 g/cm3
Solubility in water
0.5 g/L (25 C)
pKa/pKb
4.60 (pKa)
Partition coefficient, pKow
4.09

Hazards and Protection.
Protection
Wear a NIOSH/MSHA approved self-contained breathing apparatus and appropriate personal protection (rubber boots, safety goggles, and heavy rubber gloves).
Small spills/leaks
Vacuum or sweep up material and place in disposal container. Avoid raising dust. After removal, ventilate contaminated area and flush thoroughly with water.
Stability
Stable at normal temperatures and pressures.

Fire.
Fire fighting
Wear self-contained breathing apparatus pressure-demand (MSHA/NIOSH approved or equivalent), and full protective gear to prevent contact with skin and eyes. Use alcohol-resistant foam, carbon dioxide, water, or dry chemical spray when fighting fires involving this material.

Health.
Exposure effects
May be harmful by inhalation, ingestion, or skin absorption. May cause eye, skin, or respiratory system irritation. The toxicological properties of this compound have not been fully evaluated.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Never give anything by mouth to an unconscious person. Get medical attention. Do NOT induce vomiting unless directed to do so by medical personnel.
   Inhalation
If inhaled remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained personnel. Get immediate medical attention.
   Skin
In case of skin contact, immediately wash skin with soap and plenty of water. Remove contaminated clothing. Get medical attention if symptoms occur. Wash clothing before reuse.
   Eyes
In case of contact with eyes, hold eyelids apart and flush eyes with plenty of water. After initial flushings, remove any contact lenses and continue flushing for at least 20 minutes. Have eyes examined and tested by medical personnel.

Transport.