Ranitidine

  • N-(2-(((-5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine
  • 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N-methyl-2-nitro
Formula
C13H22N4O3S
Structure
Description
Off-whice to pale yellow powder with a characteristic sulfur-like odor.
Uses
Medication.

Registry Numbers and Inventories.
CAS
66357-35-5
EC (EINECS/ELINCS)
266-332-5
RTECS
KM6556500
RTECS class
Drug; Human Data
Merck
12,8286
Beilstein/Gmelin
4327819
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C13H22N4O3S
Formula mass
314.41
Melting point, °C
69-70
Solubility in water
water soluble
Partition coefficient, pKow
-1.1

Hazards and Protection.
Storage
Ranitidine hydrochloride tablets or solution should be stored in a dry place at 15-30C in tight, light-resistant containers.
Handling
Use practices that will minimize dust generation and contact.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
NIOSH/MSHA recommended respirator.
Small spills/leaks
Wear full protective equipment. Collect by carefully sweeping or vacuuming with HEPA filtered vacuum and place in a labeled, sealed container for disposal. Was area with water.
Stability
No data.
Incompatibilities
Strong oxidizing agents.
Decomposition
Toxic and corrosive vapores, chlorides, oxides of nitrogen and sulfur.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
   Ingestion
Respiratory depression may occur.
   Inhalation
Respiratory depression may occur.
   Skin
Occupational dermatitis and psoriasis have been reported.
   Eyes
Causes irritation.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.