Rapamycin

  • Antibiotic AY-22989
  • AY-22989
  • NSC-226080
  • (-)-Rapamycin
  • SILA-9268A
  • Sirolimus
Formula
C51H79NO13
Description
White to off-white powder.
Uses
Tool for immunochemistry.

Registry Numbers and Inventories.
CAS
53123-88-9
RTECS
VE6250000
Merck
12,8288
Beilstein/Gmelin
5848501
Beilstein Reference
6-27
New Zealand
Listed

Properties.
Formula
C51H79NO13
Formula mass
914.19
Melting point, °C
183 - 184
Density
1.18 g/cm3
Solubility in water
Insoluble
pKa/pKb
10.40 (pKa)
Partition coefficient, pKow
3.58

Hazards and Protection.
Storage
Store solid and solutions at -20 ºC
Protection
Protective clothing, heavy rubber gloves, chemical safety goggles.
Respirators
NIOSH/MSHA-approved respirator.
Small spills/leaks
Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol.
Stability
Stable if stored as directed.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam. Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Health.
Exposure effects
Potent immunosuppresent; may cause irritation to eyes, skin, mucous membranes.
   Ingestion
Wash out mouth with copious amounts of water; call a physician
   Inhalation
If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
   Skin
Flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
   Eyes
Check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician

First aid
 

Transport.