Rescinnamine

  • Anapral
  • Anaprel
  • Apoterin
  • Cartric
  • Cinamine
  • Cinatabs
Formula
C35H42N2O9
Structure
Description
Odorless white to cream colored crystalline powder.
Uses
Therap cat: antihypertensive.

Registry Numbers and Inventories.
CAS
24815-24-5
EC (EINECS/ELINCS)
246-471-8
RTECS
ZG0700000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,8311
Beilstein/Gmelin
75328
Beilstein Reference
4-25-00-01323
Japan ENCS (MITI)
Listed

Properties.
Formula
C35H42N2O9
Formula mass
634.73
Melting point, °C
241
Solubility in water
practically insoluble

Hazards and Protection.
Storage
Keep container closed when not in use. Store protected from light. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light. Do not breathe dust or fumes.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures. Darkens on exposure to light.
Incompatibilities
Strong oxidizing agents, direct light.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire, use carbon dioxide, dry chemical powder or water spray.
Fire potential
This material is probably combustible.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Patients may initially demonstrate elevated blood pressure and rapid heart rate for up to one day followed by abnormally low blood pressure and low heart rate. CNS depression occurs, ranging from drowsiness, lethargy, and mental depression through stupor and coma. Peripheral responses are biphasic: initially they may demonstrate catecholamine release, then depletion. Parkinsonism may develop in patients being treated with reserpine, particularly at higher dosages. Reserpine crosses the placenta, and is excreted in breast milk.
   Ingestion
May cause central nervous system depression. May be harmful if swallowed. Overexposure may cause excessive drowsiness, hypotension, fatigue, weakness, insomnia, nightmares, excitement, irrational behavior, and parkinsonian rigidity.
   Inhalation
May cause rhinitis. Causes nasal congestion, increased bronchiolar secretion and constrict ion, edema, possible heart failure. Aggrivates dermatological disorde rs by cutaneous vasodilation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.