Reserpine

  • Temposerpine
  • Crystoserpine
  • Vio-Serpine
  • 3,4,5-Trimethoxybenzoyl methyl reserpate
  • 11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
  • Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester, (3b,16b,17a,18b,20a)-
Formula
C33H40N2O9
Structure
Description
White or cream to slightly yellow crystals or crystalline powder. Odorless with a bitter taste.
Uses
Antihypertensive, central depressant, and sedative drug for both humans and animals.

Registry Numbers and Inventories.
CAS
50-55-5
EC (EINECS/ELINCS)
200-047-9
R 45 61 20/21/22
RTECS
ZG0350000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Natural Product
UN (DOT)
2811
Merck
12,8314
Beilstein/Gmelin
102014
Beilstein Reference
4-25-00-01319
RCRA
U200
EPA OPP
123101
Swiss Giftliste 1
G-4349
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C33H40N2O9
Formula mass
608.69
Melting point, °C
262
Decomposition point, °C
264-265
Solubility in water
Insoluble
pKa/pKb
6.75 (pKb)

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Do not breathe dust, vapor, mist, or gas. Keep container tightly closed.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions. Darkens and decomposes on exposure to light.
Incompatibilities
Oxidizing agents.
Decomposition
Carbon monoxide, oxides of nitrogen, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This material is probably combustible.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OSHA: Possible Select carcinogen
Carcinogin
N-2, CP65
Poison_Class
2
Exposure effects
May cause cancer according to animal studies. Reproductive effects have been reported in animals.
   Ingestion
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system effects such as psychosis, hallucinations, depression, visual changes and mental changes. May cause nausea, vomiting, and drowsiness.
   Inhalation
May cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. Get medical aid. Support breathing as needed. DO NOT use mouth-to-mouth respiration.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III
 
USCG CHRIS Code
RSR