Retrorsine

  • b-Longilobine
  • 12,18-Dihydroxy-senecionan-11,16-dione
Formula
C18H25NO6
Structure
Description
Colorless prisms.
Uses
Used to induce liver damage, tumors in laboratory rats.

Registry Numbers and Inventories.
CAS
480-54-6
RTECS
VH7525000
RTECS class
Tumorigen; Drug; Mutagen; Natural Product
Merck
12,8335
Beilstein/Gmelin
96705
Beilstein Reference
4-27-00-06663

Properties.
Formula
C18H25NO6
Formula mass
351.4
Melting point, °C
216 - 216.5
Solubility in water
Slightly soluble
pKa/pKb
5.37 (pKa)

Hazards and Protection.
Storage
For long periods the substance is best stored under nitrogen at -15C.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Volatility: Low; stable at room temperature in closed containers.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
headache as well as apathy has been reported.
   Ingestion
Right pleural effusion was seen in a 6-month-old given PA-containing herbal tea.
   Inhalation
Right pleural effusion was seen in a 6-month-old given PA-containing herbal tea.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.