Rifampin

  • R/amp
  • 3-((4-methyl-1-piperazinyl)iminomethyl)rifamycin sv
  • 8-(4-Methylpiperazinyliminomethyl) rifamycin sv
  • 8-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin sv
  • Rifa
  • Rifadin
Formula
C43H58N4O12
Structure
Description
Red to orange platelets from acetone. Odorless.
Uses
Medication.

Registry Numbers and Inventories.
CAS
13292-46-1
EC (EINECS/ELINCS)
236-312-0
EC Class
harmful
RTECS
VJ7000000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,8382
Beilstein/Gmelin
605085
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C43H58N4O12
Formula mass
822.95
Melting point, °C
183 - 188
Solubility in water
slightly soluble

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from light.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Animal studies have reported that fetal effects/abnormalities may occur when maternal toxicity is seen. Chronic exposure may cause liver damage. Chronic exposure may cause kidney damage. Animal studies have reported the development of tumors. Cancer suspect agent.
   Ingestion
May cause irritation of the digestive tract. May cause liver and kidney damage. Human fatalities have been reported from acute poisoning. May be harmful if swallowed.
   Inhalation
May cause respiratory tract irritation. May cause liver and kidney damage. May cause cardiac abnormalities.
   Skin
May cause skin irritation. May cause dermatitis.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
HS Code
2941 90 00