Riluzole

  • Benzothiazole, 2-amino-6-trifluoromethoxy
  • 2-Amino-6-trifluoromethoxybenzothiazole
  • 2-Benzothiazolamine, 6-(trifluoromethoxy)
  • 6-(Trifluoromethoxy)-2-aminobenzothiazole
  • PK-26124
Formula
C8H5F3N2OS
Structure
Description
Powder.

Registry Numbers and Inventories.
CAS
1744-22-5
RTECS
DL2830000
Merck
12,8389

Properties.
Formula
C8H5F3N2OS
Formula mass
234.2
Melting point, °C
117
Boiling point, °C
296
Vapor pressure, mmHg
0.0015 (25 C)
Density
1.572 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
10.45 (pKb)
Partition coefficient, pKow
2.84
Heat of vaporization
53.6 kJ/mol

Hazards and Protection.
Storage
Store at room temperature in a tightly sealed container.
Protection
PVC or other plastic gloves. Protective work clothing. Safety glasses with side-shields.
Small spills/leaks
Eliminate all ignition sources. Absorb and/or contain spill with inert materials (e.g., sand, vermiculite). Then place in appropriate container. For large spills, use water spray to disperse vapors, flush spill area. Prevent runoff from entering waterways or sewers.
Incompatibilities
Oxidizing and spontaneously flammable products.

Fire.
Flash Point,°C
133
Fire fighting
Extinguish using dry chemical, CO2, water spray or alcohol foam. Wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Water mist may be used to cool closed containers.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
Chronic toxicity: Chronic exposure may cause nausea and vomiting, higher exposure causes unconsciousness. Local effects: Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting. Specific effects: May include moderate to severe erythema (redness) and moderate edema (raised skin), nausea, vomiting, headache.

First aid
 
   Ingestion
Do not induce vomiting without medical advice.
   Inhalation
Move to fresh air. Call a physician immediately.
   Skin
Rinse immediately with plenty of water and seek medical advice.
   Eyes
In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Transport.