S-(-)-Carbidopa

  • N-Aminomethyldopa
  • S-(-)-a-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid
  • L-alpha-Methyldopahydrazine
  • Hydrazino-a-methyldopa
  • L-a-Hydrazino-a-methyl-b-(3,4-dihydroxyphenyl)propionic acid
  • L-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid
Formula
C10H14N2O4.H2O
Structure
Uses
Peripheral inhibitor ofL-aromatic amino acid decarboxylase. When administered simultaneously withL-DOPA, it prevents extracerebral conversion to dopamine.

Registry Numbers and Inventories.
CAS
28860-95-9
EC (EINECS/ELINCS)
249-271-9
RTECS
MW5298000
RTECS class
Drug; Mutagen; Reproductive Effector
Merck
12,1843
Beilstein/Gmelin
657532
Beilstein Reference
5-15
Canada DSL/NDSL
DSL

Properties.
Formula
C10H14N2O4.H2O
Formula mass
244.25
Melting point, °C
206 - 208
Boiling point, °C
419
Vapor pressure, mmHg
5E-12 (25 C)
Solubility in water
Very soluble
pKa/pKb
3.40 (pKa)
Partition coefficient, pKow
0.46
Heat of vaporization
84.6 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place. Store at -20 C
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Avoid contact and inhalation.
   Inhalation
Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Transport.