Safrole

  • 4-Allyl-1,2-(methylenedioxy)benzene
  • 5-Allyl-1,3-benzodioxole
  • 5-(2-Propenyl)-1,3-benzodioxole
  • 3-(3,4-Methylenedioxyphenyl)prop-1-ene
  • Allylpyrocatechol methylene ether
  • Allyldioxybenzene methylene ether
Formula
C10H10O2
Structure
Description
Clear colorless or slightly yellow liquid with the odor of sassafras.
Uses
In manufacture of piperonyl butoxide.

Registry Numbers and Inventories.
CAS
94-59-7
EC (EINECS/ELINCS)
202-345-4
EC Index Number
605-020-00-9
EC Class
Carcinogenic Category 2; Mutagenic Category 3; Harmful
RTECS
CY2800000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Natural Product; Primary Irritant
UN (DOT)
1851
Merck
12,8468
Beilstein/Gmelin
136380
Beilstein Reference
5-19-01-00553
RCRA
U203
EPA OPP
97901
Swiss Giftliste 1
G-4057
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C10H10O2
Formula mass
162.19
Melting point, °C
11.2
Boiling point, °C
232
Vapor pressure, mmHg
0.9 (25 C)
Vapor density (air=1)
5.6
Density
1.104 g/cm3
Solubility in water
Insoluble
Viscosity
2.29 cp (25 C)
Refractive index
1.53
Partition coefficient, pKow
3.10
Heat of vaporization
45.1 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
97
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Extinguishing media: Use agent most appropriate to extinguish fire. Cool containers with flooding quantities of water until well after fire is out. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This chemical is combustible.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
OSHA: Possible Select carcinogen.
Carcinogin
I-2B, N-2, CP65
Poison_Class
1*
Exposure effects
May cause cancer according to animal studies. May cause reproductive and fetal effects. Chronic exposure may cause liver damage.
   Ingestion
May cause irritation of the digestive tract. May cause liver damage. May cause cyanosis, weakness, acidosis, and shock. May be harmful if swallowed.
   Inhalation
May cause respiratory tract irritation. May cause effects similar to those described for ingestion.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
1851
Response guide
USCG CHRIS Code
SAF