Salicylamide

  • 2-Hydroxybenzamide
  • 2-Carboxamidophenol
  • Algamon
  • Oramid
  • Salicylic acid amide
  • Urtosal
Formula
C7H7NO2
Structure
Description
White or slightly pink crystalline powder.
Uses
Medication.

Registry Numbers and Inventories.
CAS
65-45-2
EC (EINECS/ELINCS)
200-609-3
R 22 36/37/38
S 22 26 36/37/39
RTECS
VN6475000
RTECS class
Drug; Reproductive Effector; Primary Irritant
Merck
12,8480
Beilstein/Gmelin
742439
Beilstein Reference
4-10-00-00169
Swiss Giftliste 1
G-2839
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C7H7NO2
Formula mass
137.14
Melting point, °C
137
Boiling point, °C
318
Vapor pressure, mmHg
0.0002 (25 C)
Density
1.33 g/cm3 (20 C)
Solubility in water
2 g/L (20 C)
Refractive index
1.562 (20 C)
pKa/pKb
8.37 (pKa)
Partition coefficient, pKow
1.28
Heat of vaporization
58.2 kJ/mol
Heat of combustion
-3352 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures. May discolor on exposure to light.
Incompatibilities
Acids (mineral, non-oxidizing, e.g. hydrochloric acid, hydrofluoric acid, muriatic acid, phosphoric acid), acids (mineral, oxidizing, e.g. chromic acid, hypochlorous acid, nitric acid, sulfuric acid), metals (alkali and alkaline, e.g. cesium, potassium, sodium), metals and metal compounds (toxic, e.g. beryllium, lead acetate, nickel carbonyl, tetraethyl lead), oxidizing agents (strong, e.g. bromine, hydrogen peroxide, nitrogen dioxide, potassium nitrate), reducing agents (strong, e.g. aluminum carbide, chlorosilane, hydrogen phosphide, lithium hydride), water reactive substances (e.g. acetic anyhdride, alkyl aluminum chloride, calcium carbide, ethyl dichlorosilane).
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
146
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire potential
This material is probably combustible.

Health.
Poison_Class
3
Exposure effects
studies with animals indicate that salicylamide overdoses may produce central nervous system depression (rather than CNS stimulation sometimes seen early in salicylate poisonings.)
   Ingestion
May cause irritation of the digestive tract. Overexposure may produce CNS depression, hypotension, eventually respiratory arrest, but does not produce excitement, seizures, acidosis, or hypoprothrombinemia. May be harmful if swallowed.
   Inhalation
Inhalation of dust may cause respiratory tract irritation.
   Skin
May cause skin irritation.
   Eyes
Causes eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.