Salicylic acid

  • o-Hydroxybenzoic acid
  • 2-Hydroxybenzoic acid
Formula
HOC6H4COOH
Structure
Description
White crystals, usually in fine needles, or fluffy crystalline powder. Odorless and has a sweetish, followed by acrid taste.
Uses
Manufacture of aspirin and salicylates, resins, dyestuff intermediate, prevulcanisation inhibitor, analytical reagent, fungicide.

Registry Numbers and Inventories.
CAS
69-72-7
EC (EINECS/ELINCS)
200-712-3
EC Class
harmful, irritant
R 22 36/37/38
S 26 36/37/39
RTECS
VO0525000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Merck
12,8484
Beilstein/Gmelin
774890
Beilstein Reference
4-10-00-00125
EPA OPP
76602
Swiss Giftliste 1
G-2840
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H6O3
Formula mass
138.12
Boiling point, °C
336
Vapor pressure, mmHg
4.5E-5
Vapor density (air=1)
4.8
Density
1.443 g/cm3
Solubility in water
Very soluble
Viscosity
1.45 cp (153 C)
Refractive index
1.5204
pKa/pKb
2.97 (pKa)
Partition coefficient, pKow
2.26
Heat of fusion
18.2 kJ/mol
Heat of vaporization
61.2 kJ/mol
Heat of combustion
-588 kJ/mol

Hazards and Protection.
Storage
Keep away from sources of ignition. Do not store in direct sunlight. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Stability
Stable under normal temperatures and pressures. Moisture sensitive. Light sensitive. Darkens on exposure to light.
Incompatibilities
Oxidizing agents, lead acetate, iron salts, alkalis, iodine, spirit nitrous ether.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
145
Autoignition, °C
500
Upper exp. limit, %
8.6
Lower exp. limit, %
1.5
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Water or foam may cause frothing. Use agent most appropriate to extinguish fire.
Fire potential
Slightly. Requires preheating. Slight hazard.
Hazards
Dusts at sufficient concentrations can form explosive mixtures in air.
Combustion products
Irritating vapors of unburned material and phenol may form in fire.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Poison_Class
3
Exposure effects
May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. May cause salicylism with effects similar to those of skin absorption. May cause damage to the kidneys and pancrease.
   Ingestion
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause salicylism; characterized by headache, dizziness, ringing in the ears, hearing difficulty, visual disturbances, mental confusion, drowsiness, sweating thirst, hyperventilation, nausea, vomiting and diarrhea. May be harmful if swallowed. Severe salicylate intoxication may cause central nervous system disturbances such as convulsions and coma, skin eruptions, and alteration in the acid-base balance.
   Inhalation
Causes irritation of the mucous membrane and upper respiratory tract.
   Skin
Contact with skin causes irritation and possible burns, especially if the skin is wet or moist. If absorbed, may cause symptoms similar to those for ingestion. May cause skin rash and eruptions.
   Eyes
Causes severe eye irritation. May result in corneal injury.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Induce vomiting by giving one teaspoon of Syrup of Ipecac.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
USCG CHRIS Code
SLA
 
HS Code
2918 21 00