Saxitoxin dihydrochloride

  • Clam poison dihydrochloride
  • Gonyaulax toxic dihydrochloride
  • Mussel poison dihydrochloride
  • Paralytic shellfish poison dihydrochloride
  • Saxitoxin hydrochloride
  • Stx dihydrochloride
Formula
[C10H17N7O4]++
Structure
Description
White solid.
Uses
As a tool in neurochemical research. Saxtoxin.

Registry Numbers and Inventories.
CAS
35554-08-6
RTECS
UY8708600
RTECS class
Drug; Natural Product
Merck
12,8533
Beilstein/Gmelin
4927102
Beilstein Reference
4-26-00-04028
New Zealand
Listed

Properties.
Formula
C10H17N7O4*2ClH
Formula mass
371.09
Solubility in water
Very soluble
pKa/pKb
2.40 (pKb)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Stable in acid solution; decomposes rapidly in alkaline media. Very stable can be heated in water solution @ 120 C without loss of activity boiling 3-4 hr @ pH 3 causes loss of activity.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Initially, paresthesias (pins and needles) and numbness of lips, tongue, face, neck and extremities may occur. Headaches, dizziness, drowsiness, and a sensation of lightness have also been reported.
   Ingestion
Nausea, vomiting, diarrhea, and abdominal pain may occur following exposure.
   Inhalation
Respiratory distress and death due to respiratory paralysis may occur within the first 12 hours.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.