Secobarbital

  • 5-Allyl-5-(1-methylbutyl)barbiturate
  • 5-Allyl-5-(1-methylbutyl)barbituric acid
  • 5-Allyl-5-(1-methylbutyl)malonylurea
  • Evronal
  • Hypotrol
  • Immenox
Formula
C12H18N2O3
Structure
Description
White, amorphous or crystalline powder. Odorless.
Uses
This is a drug of abuse.

Registry Numbers and Inventories.
CAS
76-73-3
EC (EINECS/ELINCS)
200-982-2
RTECS
CP9450000
RTECS class
Drug; Human Data
Beilstein/Gmelin
225330
Beilstein Reference
5-24-09-00235
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C12H18N2O3
Formula mass
238.28
Melting point, °C
96 - 98
Solubility in water
Slightly soluble
Refractive index
1.4936
pKa/pKb
7.90 (pKa)
Partition coefficient, pKow
1.97
Heat of fusion
17.4 kJ/mol

Hazards and Protection.
Storage
Store in airtight containers store quinabarbitone capsules at a Ideal materials for s exceeding 30C. Refrigerate allsolution to maintain indefinite stability. Store below 40C (104F), preferably between 15 and 30C (59 and 86F), unless otherwise specified by manufacturer. Store in a tight container.
Handling
Avoid eye or skin contact. Avoid breathing vapors. Use only in well ventilated area.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
NIOSH/MSHA approved face mask with organic vapor canister.
Small spills/leaks
Sweep up, avoiding dust generation -- or take up with an inert absorbent.
Stability
Stable.
Incompatibilities
Strong oxidizing agents.
Decomposition
No data.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
CNS findings range from drowsiness to deep coma. Seizures are not expected, except upon withdrawal from barbiturate dependence.
   Ingestion
Respiratory arrest may occur following severe intoxication. Aspiration pneumonia has been reported, in barbiturate ingestions, following vomiting of gastric contents.
   Inhalation
Respiratory arrest may occur following severe intoxication. Aspiration pneumonia has been reported, in barbiturate ingestions, following vomiting of gastric contents.
   Skin
Erythematous or hemorrhagic blisters (barb - burns) may occasionally occur on the hands, buttocks, in between the knees, and at any pressure point.
   Eyes
May cause irritation, blindness.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.