Securinine, (-)

  • Securinan-11-one
  • Securinin
  • Securinine
  • (-)-Securinine
  • 6,10-Methanopyrido[1,2-a]azepine-9(6H),a-acetic acid, 1,2,3,4,10,10a-hexahydro-10-hydroxy-, g-lactone
  • 8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one, 9,10,11,11a-tetrahydro-, (6S,11aR,11bS)-
Formula
C13H15NO2
Structure

Registry Numbers and Inventories.
CAS
5610-40-2
23/24/25
36/37/39 45
RTECS
VS4115000
Merck
12,8565

Properties.
Formula
C13H15NO2
Formula mass
217.27
Melting point, °C
146
Boiling point, °C
459
Vapor pressure, mmHg
1.3E-8 (25 C)
Density
1.30 g/cm3 (20 C)
Solubility in water
0.74 g/L (25 C)
pKa/pKb
5.71 (pKb)
Partition coefficient, pKow
0.80
Heat of vaporization
71.94 kJ/mol

Hazards and Protection.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles. Protective clothing.
Respirators
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N99 (US) or type P2 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Decomposition
Carbon monoxide, carbon dioxide, and nitrogen oxides.

Fire.
Flash Point,°C
196
Fire fighting
Extinguish with water spray, carbon dioxide, dry chemical powder or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Harmful if swallowed, inhaled, or absorbed through skin. Causes strychnine-like stimulation of spinal cord, but 15 to 20 times weaker. At the same time, it also shows a stimulating action on the mid-brain or other upper parts of the brain stem.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.