Sinomenine

  • Cucoline
  • (9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one
Formula
C19H23NO4
Structure
Description
A toxic crystalline alkaloid from the root of Sinomenium acutum, structurally related to thebaine.
Uses
Anti-inflammatory.

Registry Numbers and Inventories.
CAS
115-53-7
EC (EINECS/ELINCS)
204-094-6
45 46 23/24/25 36/37/38
53 22 26 36/37/39 45
RTECS
QD2170000
RTECS class
Drug
Merck
12,8692
Beilstein/Gmelin
95280
Beilstein Reference
5-21-13-00516

Properties.
Formula
C19H23NO4
Formula mass
329.4
Melting point, °C
219 - 221
Boiling point, °C
513
Vapor pressure, mmHg
3E-11 (25 C)
Solubility in water
Insoluble
Refractive index
 
pKa/pKb
9.71 (pKa)
Heat of vaporization
81.5 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas, Phosgene gas.

Fire.
Flash Point,°C
264
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
May cause cancer. May cause heritable genetic damage. Toxic by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Target organ(s): Liver. Kidneys.
   Inhalation
Material is irritating to mucous membranes and upper respiratory tract.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.