Sodium levothyroxine pentahydrate

  • L-Thyroxine sodium salt pentahydrate
  • 3',3,5',5-Tetraiodo-L-thyronine sodium salt pentahydrate
  • L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt, pentahydrate
Formula
C15H11I4NO4
Structure
Description
Odorless beige grey solid
Uses
The major hormone derived from the thyroid gland. It is used to treat hypothyroidism.

Registry Numbers and Inventories.
CAS
6106-07-6
RTECS
YP2833760
RTECS class
Reproductive Effector
UN (DOT)
2811
Beilstein/Gmelin
NA

Properties.
Formula
C15H11I4NO4
Formula mass
776.87
Melting point, °C
207
Vapor density (air=1)
30.6
Density
2.381 g/cm3 (20 C)

Hazards and Protection.
Storage
Store in a cool, dry place. Hormones and antibiotics room. Keep containers tightly closed.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Explosion hazard when mixed with strong oxidizers.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen iodide, iodide ions (I-).

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. Extinguishing media: Use alcohol foam, carbon dioxide, or water spray when fighting fires involving this material.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
Chronic exposure can lead to iodism characterized by salivation, nasal discharge, sneezing, conjunctivitis, fever, laryngitis, bronchitis, stomatitis, and skin rashes.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause thyroid abnormalities. Ingestion increases the metabolic rate causing warm, flushed and moist skin, muscular weakness, rapid heart rate, insomnia, nervousness, increased metabolism and weight loss. Effects may be delayed.
   Inhalation
May cause respiratory tract irritation. May cause effects similar to those described for ingestion.
   Skin
May cause skin irritation.
   Eyes
May cause severe eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid if irritation develops or persists. Wash clothing before reuse. Flush skin with plenty of soap and water.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III