Spermidine

  • N-(3-Aminopropyl)-1,4-butanediamine
Formula
NH2(CH2)4NH(CH2)3NH
Structure
Description
White chunks.
Uses
Used as a a tool in biochemical research.

Registry Numbers and Inventories.
CAS
124-20-9
EC (EINECS/ELINCS)
204-689-0
S 26 36/37/39 45
RTECS
EJ7000000
RTECS class
Drug; Mutagen
UN (DOT)
1760
Merck
12,8893
Beilstein/Gmelin
1698591
Beilstein Reference
4-04-00-01300
Canada DSL/NDSL
DSL
US TSCA
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C7H19N3
Formula mass
145.25
Melting point, °C
20 - 25
Boiling point, °C
246
Vapor pressure, mmHg
0.03 (25 C)
Density
0.925 g/cm3 (20 C)
Solubility in water
Very soluble
Refractive index
1.48 (20 C)
pKa/pKb
3.49 (pKb)
Partition coefficient, pKow
-0.84
Heat of vaporization
48.4 kJ/mol

Hazards and Protection.
Storage
Keep container closed when not in use. Refrigerator (approx 4 C). Do not expose to air. Store under an inert atmosphere.
Handling
Wash thoroughly after handling. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use with adequate ventilation. Handle under an inert atmosphere. Store protected from air. Use only in a chemical fume hood. Discard contaminated shoes. Do not breathe vapors.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Cover with sand, dry lime or soda ash and place in a closed container for disposal. Provide ventilation. Place under an inert atmosphere.
Stability
Stable under normal temperatures and pressures. May decompose on exposure to air.
Incompatibilities
Oxidizing agents, acids, acid chlorides, acid anhydrides, air.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
118
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
3
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Effects may be delayed.
   Ingestion
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May cause systemic effects.
   Inhalation
Causes chemical burns to the respiratory tract. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. Aspiration may lead to pulmonary edema. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
   Skin
Causes skin burns. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
   Eyes
Causes eye burns. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
1760
Response guide
Hazard class
8
Packing Group
I; II; III