Spermine

  • Gerontine
  • Musculamine
  • 4,9-Diazadodecane-1,12-diamine
  • N,N'-Bis(3-aminopropyl)-1,4-butanediamine
  • N,N'-Bis(3-aminopropyl)-1,4-tetramethylenediamine
Formula
H2N(CH2)3NH(CH2)4NH
Structure
Description
White chunks.
Uses
Used as a a tool in biochemical research.

Registry Numbers and Inventories.
CAS
71-44-3
EC (EINECS/ELINCS)
200-754-2
S 26 36/37/39 45
RTECS
EJ7175000
RTECS class
Mutagen
UN (DOT)
1760
Merck
12,8894
Beilstein/Gmelin
1750791
Beilstein Reference
4-04-00-01301
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C10H26N4
Formula mass
202.34
Melting point, °C
66
Boiling point, °C
308
Vapor pressure, mmHg
0.0007 (5 C)
Solubility in water
Very soluble
Refractive index
1.488 (26 C)
pKa/pKb
3.14 (pKb)
Partition coefficient, pKow
-0.96
Heat of vaporization
54.9 kJ/mol

Hazards and Protection.
Storage
Refrigerator (approx 4 C).
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate safety goggles, protective clothing and gloves.
Respirators
Not available.
Small spills/leaks
ELIMINATE all ignition sources. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
Stability
No data.

Fire.
Flash Point,°C
175
Fire fighting
Extinguish using agent most appropriate for surrounding fire.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
   Ingestion
Not available.
   Inhalation
May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Causes chemical burns to the respiratory tract.
   Skin
May cause severe irritation and possible burns.
   Eyes
Contact with eyes may cause severe irritation, and possible eye burns.

First aid
 
   Ingestion
Do NOT induce vomiting.
   Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1760
Response guide
Hazard class
8
Packing Group
I; II; III