Spironolactone

  • Verospirone
  • Nefurofan
  • 3-(3-Oxo-7a-acetylthio-17b-hydroxy-4-androsten-17a-yl)propionic acid-g-lactone
  • 3'-(3-Oxo-7a-acetylthio-17b-hydroxyandrost-4-en-17a-yl)-propionic acid lactone
  • Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, g-lactone, (7a,17a)-
Formula
C24H32O4S
Structure
Description
White powder.
Uses
Diuretic.

Registry Numbers and Inventories.
CAS
52-01-7
EC (EINECS/ELINCS)
200-133-6
RTECS
TU4725000
RTECS class
Tumorigen; Drug; Reproductive Effector; Human Data
Merck
12,8917
Beilstein/Gmelin
57767
Beilstein Reference
4-18-00-01601
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
Korea ECL
Listed

Properties.
Formula
C24H32O4S
Formula mass
416.58
Melting point, °C
196
Boiling point, °C
597
Decomposition point, °C
100
Vapor pressure, mmHg
3E-14 (25 C)
Solubility in water
Insoluble
Partition coefficient, pKow
3.12
Heat of fusion
20.0 kJ/mol
Heat of vaporization
88.9 kJ/mol

Hazards and Protection.
Storage
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood. Do not breathe dust.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Cover with sand, dry lime or soda ash and place in a closed container for disposal. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, oxides of sulfur, carbon dioxide.

Fire.
Flash Point,°C
302
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Carcinogin
CP65
Exposure effects
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Other human systemic effects by ingestion: agranulocytosis, kidney tubule damage, increased urine volume, and changes in blood sodium and calcium levels.
   Inhalation
May cause respiratory tract irritation. May cause irritation of the mucous membranes.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.