Strophanthidin

  • Cymarigenen
  • K-Strophanthidin
  • 3b,5,14-Trihydroxy-19-oxo-5b,20(22)-cardenolide
Formula
C23H32O6
Structure
Uses
The aglycone cardioactive agent isolated from Strophanthus Kombe, S. gratus and other species; it is a very toxic material formerly used as digitalis.

Registry Numbers and Inventories.
CAS
66-28-4
EC (EINECS/ELINCS)
200-626-6
26/27/28
22 36/37/39 45
RTECS
FH5425000
RTECS class
Drug; Natural Product
UN (DOT)
2811
Merck
12,9015
Beilstein/Gmelin
97859
Beilstein Reference
5-18-05-00126

Properties.
Formula
C23H32O6
Formula mass
404.5
Melting point, °C
235
Vapor pressure, mmHg
5E-18 (25 C)
Solubility in water
Insoluble
pKa/pKb
13.91 (pKa)

Hazards and Protection.
Storage
Store at -20 C.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, Strong acids, Strong bases.
Decomposition
Carbon monoxide, Carbon dioxide.

Fire.
Fire fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
Very toxic by inhalation, in contact with skin and if swallowed. Danger: Poison. Do not breathe dust.
   Ingestion
See Inhalation.
   Inhalation
TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.
   Skin
Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.
   Eyes
See Inhalation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I