Sumatriptan

  • 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide
  • GR-43175
  • GR-43175X
  • Imigran
  • Imitrex
Formula
C14H21N3O2S
Structure
Description
Distributed as a 5 - 20% aqueous solution.

Registry Numbers and Inventories.
CAS
103628-46-2
RTECS
NL9482200
Merck
12,9172
Beilstein/Gmelin
6930870
New Zealand
Listed

Properties.
Formula
C14H21N3O2S
Formula mass
295.41
Melting point, °C
169 - 171
Boiling point, °C
498
Vapor pressure, mmHg
4.8E-10 (25 C)
Density
1.243 g/cm3 (20 C)
Solubility in water
Soluble
pKa/pKb
11.31 (pKa)
Partition coefficient, pKow
-2.3
Heat of vaporization
76.6 kJ/mol

Hazards and Protection.
Storage
No storage requirements necessary for occupational hazards. Follow product information storage instructions to maintain efficacy.
Protection
Protective gloves and clothing. Chemical safety goggles.
Small spills/leaks
Collect and place it in a suitable, properly labeled container for recovery or disposal.

Fire.
Fire fighting
For single units (packages): No special requirements needed. For larger amounts (multiple packages/pallets) of product: Since toxic, corrosive or flammable vapors might be evolved from fires involving this product and associated packaging, self contained breathing apparatus and full protective equipment are recommended for firefighters. If possible, contain and collect firefighting water for later disposal.
Fire potential
Product is non combustable.

Health.
Exposure effects
Medical treatment in cases of overexposure should be treated as an overdose of a 5-hydroxytryptamine agonist. Treat according to locally accepted protocols. For additional guidance, refer to the current prescribing information or to the local poison control information centre.

First aid
 
   Ingestion
Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the exposed subject is unconscious or semi-conscious. Wash out the mouth with water. If the exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.
   Inhalation
Physical form suggests that risk of inhalation exposure is negligible.
   Skin
Using appropriate personal protective equipment, remove contaminated clothing and flush exposed area with large amounts of water. Obtain medical attention if skin reaction occurs, which may be immediate or delayed.
   Eyes
Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain medical attention.

Transport.