Taxol

  • Paclitaxel
  • Yewtaxan
  • NSC 125973
  • 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
Formula
C47H51NO14
Structure
Description
Needles (from aqueous methanol) or fine white powder.
Uses
Tool in study of structure and function of microtubules.

Registry Numbers and Inventories.
CAS
33069-62-4
RTECS
DA8340700
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,7117
Beilstein/Gmelin
1420457

Properties.
Formula
C47H51NO14
Formula mass
853.92
Melting point, °C
213 - 216

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a dry area. Deep freeze (below -20 C).
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
No data.
Incompatibilities
Oxidizing agents.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
This material is probably combustible.

Health.
Exposure effects
sensory neuropathy of the hands and feet or mouth and tongue was reported in patients taking paclitaxel or docetaxel. Symptoms include a burning dysesthesia of the feet, numbness, and lancing pain in the back or extremities. Seizures, autonomic neuropathy, motor dysfunction, proximal muscle weakness, and coma have been occasionally described. Optic nerve disturbances have been reported following paclitaxel therapy. Paclitaxel and docetaxel may be maternal and embryo-fetal toxic and are classified as FDA Pregnancy Category D. <br>Breast-feeding is not recommended due to potential risk to the nursing infant.
   Ingestion
May cause irritation of the digestive tract. May be harmful if swallowed.
   Inhalation
May cause respiratory tract irritation. May be harmful if inhaled.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation and possible damage.

First aid
 
   Ingestion
Get medical aid. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.