Telmisartan

  • Micardis
  • 4'-[[4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid
Formula
C33H30N4O2
Structure
Uses
Angiotensin II antagonist.

Registry Numbers and Inventories.
CAS
144701-48-4
Merck
12,10509

Properties.
Formula
C33H30N4O2
Formula mass
514.63
Melting point, °C
261-263
Vapor pressure, mmHg
4.6E-25 (25 C)
Density
1.24 g/cm3
pKa/pKb
3.83 (pKa)
Partition coefficient, pKow
7.73

Hazards and Protection.
Storage
Store in a cool, dry place (25 C). The bottles should be kept tightly closed.
Protection
Wear approved respirator and chemically compatible gloves if containers have been compromised and dust is present.
Small spills/leaks
Vacuum or sweep up spillage. Avoid creating dust. Very fine particles can cause a fire or explosion; therefore, eliminate all sources of ignition. Place spillage in appropriate container for waste disposal. Wash contaminated clothing before reuse. Ventilate area, wash down spill site and control wash water.
Stability
Stable at normal temperatures and pressures.
Decomposition
When heated to decomposition or under fire conditions, material emits oxides of carbon and nitrogen.

Fire.
Fire fighting
Use water spray, foam, CO2, or dry chemical agents to extinguish fires. evacuate personnel to safe area. Firefighters should use self-contained breathing equipment and protective clothing. Use water s pray to keep fire-exposed containers cool.
Combustion products
Acrid, flammable fumes may develop in a fire.

Health.
Exposure effects
Possible reaction to dust if inhaled (breathed), ingested (swallowed), or in contact with eyes. The most common adverse events reported were upper respiratory tract infection, back pain, sinusitis, diarrhea and pharyngitis. See Package Insert for further information. The most likely manifestation of overdosage would be hypotension, dizziness, and tachycardia; bradycardia could occur from vagal stimulation. Supportive treatment should be instituted. Telmisartan is not removed by hemodialysis. CHRONIC EXPOSURE: May reduce blood pressure. MEDICAL CONDITIONS POTENTIALLY AGGRAVATED BY EXPOSURE: Dust allergies, and pre-existing respiratory conditions and anyone who is hypersensitive to any component of this product. Persons with low blood volume, and hepatic insufficiency may be at additional risk.

First aid
 
   Ingestion
Give 3-4 glasses of water, but DO NOT induce vomiting. If vomiting occurs, give fluids again. Get medical attention to determine whether vomiting or evacuation of stomach is necessary. Do not give anything by mouth to an unconscious or convulsing person.
   Inhalation
Remove from area to fresh air. Seek medical attention if respiratory irritation develops or if breathing becomes difficult.
   Skin
Wash affected areas with plenty of water, and soap if available, for several minutes. Seek medical attention if irritation develops or persists.
   Eyes
Remove contact lenses if necessary. Flush eyes with large amounts of running water for at least 15 minutes. Seek medical attention if irritation develops or persists.

Transport.