Tetracycline

  • Abramycin
  • Abricycline
  • Achromycin
  • Agromicina
  • Ambramicina
  • Ambramycin
Formula
C22H24N2O8
Structure
Description
Yellow crystalline powder. Odorless.
Uses
pharmaceutical

Registry Numbers and Inventories.
CAS
60-54-8
EC (EINECS/ELINCS)
200-481-9
RTECS
QI8750000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,9337
Beilstein/Gmelin
2230417
Beilstein Reference
4-14-00-02625
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C22H24N2O8
Formula mass
444.44
Melting point, °C
175
Density
1.46 g/cm3
Solubility in water
Soluble.
pKa/pKb
3.30 (pKa)
Partition coefficient, pKow
-1.37

Hazards and Protection.
Storage
Store away from incompatible substances in a cool, dry location. Prevent exposure to light.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear impervious protective gloves and clothing, splash proof, dust resistant safety goggles.
Respirators
Any NIOSH/MSHA approved dust-mist respirator, air purifying respirator with high-efficiency particulate filter, powdered air purifying respirator with a dust-mist filter.
Small spills/leaks
Sweep up and place in a suitable, clean, dry container for later disposal. Do not flush into sewer. Keep unnecessary people away.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizers.
Decomposition
Oxides of carbon and nitrogen.

Fire.
Flash Point,°C
>200
Fire fighting
Use dry chemical, carbon dioxide, water spray, regular foam to extinguish fire.
Fire potential
Material may burn but does not ignite readily.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Headache, papilledema and benign intracranial hypertension have been reported. Maternal ingestion of tetracyclines during pregnancy may cause tooth discoloration, enamel defects, and other congenital anomalies. <br>Hepatotoxicity, pancreatitis, and renal failure may occur in pregnant women following ingestion of tetracyclines during pregnancy.
   Ingestion
Nausea, vomiting, epigastric burning, and abdominal discomfort have been noted. Tetracycline and doxycycline have been implicated in causing esophageal ulceration, but this is thought to be uncommon.
   Inhalation
Allergic reaction, anaphylatic reactions, profuse rhinorrea, sensitization.
   Skin
Skin hyperpigmentation has been reported.
   Eyes
Transient irritation.

First aid
 
   Ingestion
If vomiting occurs, keep head lower than hips to prevent aspiration.
   Inhalation
remove to fresh air. If breathing has stopped, give CPR. Keep warm.
   Skin
Wash with soap and water for 15 - 20 minutes.
   Eyes
Immediately wash with larg amounts of water or normal saline for 15-20 minutes.

Transport.