Tetrahydrocannabinol

  • Dronabinol
  • Marijuana
  • Marinol
  • (-)-delta 9-trans-Tetrahydrocannabinol
  • delta 1-Tetrahydrocannabinol
  • delta 9-Tetrahydrocannabinol
Formula
C21H30O2
Structure
Description
Oil.
Uses
Medication.

Registry Numbers and Inventories.
CAS
1972-08-3
RTECS
HP8225000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Natural Product
Beilstein/Gmelin
23917
Beilstein Reference
5-17-04-00423

Properties.
Formula
C21H30O2
Formula mass
314.46
Boiling point, °C
200
Solubility in water
2.8 mg/L@ 23 C
pKa/pKb
10.6 (pKa)
Partition coefficient, pKow
6.97

Hazards and Protection.
Storage
Store in a cool place in airtight containers. A 50% solution in alcohol lost about 10% of delta-9-tetrahydrocannabinol after storage at 5C for 40 days; there was greater deterioration at 22C as measured by the optical density. When cannabis was stored at -18C, 4C, and 22C, the content of delta 9-tetrahydrocannabinol was reduced by 3.8, 5.3, And 6.9% Respectively per year. There was greater deterioration at higher temperature.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Readily degraded in acid solutions.
Incompatibilities
Unstable to light and high temperatures It should be protected from air during all handling due to its extreme instability Flammable and/or toxic gases are generated by combination with with alkali metals, nitrides, and strong reducing agents Reacts with oxoacids and carboxylic acids to form esters plus water Incompatible with oxidizing agents.

Fire.
Fire fighting
Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Exposure effects
a low level intoxication usually presents with drowsiness, euphoria, heightened sensory awareness, feeling of well being, and alteration of time perception. Moderate intoxication presents with memory impairment, depersonalization, and mood alterations. High levels are associated with decreased motor coordination, lethargy, and slurred speech. Apprehensive patients may experience panic reactions. Seizures may occur in patients with existing seizure disorders.
   Ingestion
Increased appetite and reduced bowel motility have been reported.
   Inhalation
Large doses of smoked marijuana may cause irritation and coughing. A dose-related bronchodilator effect follows both ingestion and inhalation. Long term smoking of marijuana has been associated with chronic respiratory syndromes.

First aid
 
   Ingestion
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
20. Alcohols. Glycols