Tetramisole hydrochloride

  • DL-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride
  • Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (+/-)
Formula
C11H12N2S.HCl
Structure
Description
White crystals.
Uses
An anthelmintic in the treatment of many nematodes particularly in veterinary applications.

Registry Numbers and Inventories.
CAS
5086-74-8
EC (EINECS/ELINCS)
225-799-5
RTECS
NJ5950000
RTECS class
Human Data
Beilstein/Gmelin
4358988
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C11H12N2S*ClH
Formula mass
240.75
Melting point, °C
232
Heat of fusion
25.2 kJ/mol

Hazards and Protection.
Storage
Keep containers tightly closed. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.

Fire.
Autoignition, °C
500
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Health
2
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
   Ingestion
Harmful if swallowed. The toxicological properties of this substance have not been fully investigated. Causes gastrointestinal tract irritation. Systemic exposure may cause skin dermatitis.
   Inhalation
The toxicological properties of this substance have not been fully investigated. Causes irritation of the mucous membrane and upper respiratory tract.
   Skin
Causes skin irritation. The toxicological properties of this material have not been fully investigated.
   Eyes
Causes eye irritation. May cause chemical conjunctivitis.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.