Tetrodotoxin

  • Babylonia japonica toxin 1
  • 12-(Hydroxymethyl)-2-Imino-5,9:7,10a-dimethano-10ah-(1,3)dioxocino(6,5-D)
  • Fugu poison
  • Maculotoxin
  • (4R-(4-alpha,4-alpha,5-alpha,7-alpha,9-alpha,10-alpha,10abeta,11s*,12s*))-Octahydro
Formula
C11H17N3O8
Structure
Description
White to beige powder.
Uses
Physiological studies.

Registry Numbers and Inventories.
CAS
4368-28-9
EC (EINECS/ELINCS)
224-458-8
RTECS
IO1450000
RTECS class
Natural Product
UN (DOT)
2811
Merck
12,9382
Beilstein/Gmelin
49176
Beilstein Reference
4-27-00-08206
New Zealand
Listed

Properties.
Formula
C11H17N3O8
Formula mass
319.27
Melting point, °C
220
Solubility in water
Slightly soluble
pKa/pKb
8.76 (pKa)

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
3
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
All voluntary muscles, including the respiratory muscles, are rapidly weakened. Weakness develops first in the hands and arms and then in the legs. Paresthesias and dizziness may be seen. Seizures are rare, but have been reported. Repeated exposure may cause CNS damage.
   Ingestion
Poison by ingestion.
   Inhalation
The toxicological properties of this substance have not been fully investigated. Toxic if inhaled.
   Skin
Toxic in contact with skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid immediately. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III