Thalidomide

  • 2,6-Dioxo-3-phthalimidoglutarimide
  • 2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
  • Neurosedyn
  • Kevadon
  • n-(2,6-Dixo-3-piperidyl)phthalimide
  • a-Phthalimidoglutarimide
Formula
C13H10N2O4
Structure
Description
Needles or white powder.
Uses
Medication.

Registry Numbers and Inventories.
CAS
50-35-1
EC (EINECS/ELINCS)
200-031-1
RTECS
TI4375000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,9390
Beilstein/Gmelin
30233
Beilstein Reference
5-22-13-00224

Properties.
Formula
C13H10N2O4
Formula mass
258.23
Melting point, °C
276 - 278
Density
1.48 g/cm3
Solubility in water
45-60 mg/L @ 25 C
Partition coefficient, pKow
0.33

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
No data.
Incompatibilities
Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents Can react as acids.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Exposure effects
Lowered blood pressure and fever may occur following overdoses. CNS effects following overdoses have included sedation. With therapeutic use - adverse effects following therapeutic doses have included CNS depression with sedation, fatigue and dizziness. Peripheral neuropathy has been reported following long-term use of thalidomide.
   Inhalation
Symptoms of exposure to this compound include peripheral neuritis, numbness, paresthesias in the extremities and signs of motor neuron disease. Other symptoms include teratogenic effects and peripheral neuropathy. Exposure to this type of compound may lead to sleepiness, mental confusion, unsteadiness, coma with slow, shallow respiration, flaccid muscles, cyanosis, hypotension, hypothermia or hyperthermia, absent reflexes, pulmonary edema, atelectasis or aspiration pneumonia with signs of lung consolidation and fever, acidosis and fetal injury. Death occurs most often from pneumonia, pulmonary edema or refractory hypotension.
   Skin
Skin rashes are a frequently reported adverse effect.
   Eyes
See inhalation

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.