Thapsigargin

  • Azuleno[4,5-b]furan, octanoic acid deriv.
Formula
C34H50O12
Structure
Description
Clear film.
Uses
Reagent for defining and manipulating intracellular calcium pools.

Registry Numbers and Inventories.
CAS
67526-95-8
Merck
12,10394
Beilstein/Gmelin
4649292

Properties.
Formula
C34H50O12
Formula mass
650.76
Solubility in water
Insoluble
pKa/pKb
10.44 (pKa)

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container. Deep freeze (below -20 C).
Handling
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment.
Stability
No data.
Incompatibilities
Oxygen.
Decomposition
Carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Health.
Exposure effects
   Ingestion
May be fatal if swallowed. May cause irritation of the digestive tract.
   Inhalation
May be fatal if inhaled. May cause respiratory tract irritation.
   Skin
May cause skin irritation. May be fatal if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid immediately. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.