Thiabendazole

  • Apl-luster
  • 4-(2-Benzimidazolyl)thiazole
  • Biogard
  • Bovizole
  • Captan t
  • Eprofil
Formula
C10H7N3S
Structure
Description
White or cream-colored odorless, tasteless powder. Fluoresces in acidic solution.
Uses
Fungicide.

Registry Numbers and Inventories.
CAS
148-79-8
EC (EINECS/ELINCS)
205-725-8
EC Index Number
613-054-00-0
EC Class
Dangerous for the Environment
RTECS
DE0700000
RTECS class
Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Reproductive Effector; Human Data
Merck
12,9426
Beilstein/Gmelin
611403
EPA OPP
60101
Swiss Giftliste 1
G-3711
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C10H7N3S
Formula mass
201.25
Melting point, °C
304-305
Sublimation point, °C
310
Vapor pressure, mmHg
4E-9
Solubility in water
3.84% @ pH 2.2
Partition coefficient, pKow
1.94

Hazards and Protection.
Storage
Thiabendazole tablets and oral suspension should be stored in tight containers.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Non-volatile @ room temperature; stable in water and in acid and alkaline solution; stable under normal conditions to hydrolysis, light and heat.
Incompatibilities
Incompatible with a number of pesticides, including copper-containing fungicides, and with highly alkaline materials.

Fire.
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Poison_Class
4
Exposure effects
Fever is an idiosyncratic reaction with mebendazole. mental status changes (drowsiness, dizziness, irritability) and headaches have been reported during therapeutic use; one case of seizures and one case of guillain-barre syndrome have been reported.
   Ingestion
Nausea, vomiting, diarrhea, and anorexia are common side effects.
   Inhalation
Symptoms of exposure to this compound include anorexia, nausea, vomiting, epigastric distress, vertigo, pruritus, skin rashes, diarrhea, headache, fatigue, drowsiness, hyperglycemia, xanthopsia, leukopenia, bradycardia, hypotension, crystalluria and erythema multiforme. Other symptoms include dry eyes, dry mouth, cholestatic jaundice, hypersensitivity, jaundice, parenchymal liver damage, giddiness, numbness, hyperirritability, convulsions, collapse, psychic disturbances, tinnitus, abnormal sensation in eyes, blurring of vision, hematuria, enuresis, malodor of the urine, facial flush, chills, conjunctival injection, angiodema, anaphylaxis and lymphadenopathy. Exposure may also cause fever, itching, body odor, hypotension and fainting. Central nervous system depression may occur. Decrease in pulse rate and systolic blood pressure and perianal rash may also occur.
   Skin
See inhalation.
   Eyes
Color vision disturbances and tinnitus have been reported during therapeutic use of thiabendazole.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.