Thiacetazone

  • Thiosemicarbazone
  • Benzothiozone
  • p-Acetylaminobenzaldehyde
  • Siocarbazone
  • 4'-Formylacetanilide thiosemicarbazone
  • Acetamide, N-[4-[[(aminothioxomethyl)hydrazono]methyl]phenyl]-
Formula
C10H12N4OS
Structure
Description
Yellow powder.
Uses
When combined with Isoniazid, it is used to treat tuberculosis.

Registry Numbers and Inventories.
CAS
104-06-3
EC (EINECS/ELINCS)
203-170-6
RTECS
AE3850000
RTECS class
Drug; Mutagen
Merck
12,9427
Beilstein/Gmelin
2810335
Beilstein Reference
4-14-00-00075
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C10H12N4OS
Formula mass
236.29
Melting point, °C
246 - 247
Density
1.368 g/cm3
Solubility in water
Insoluble
pKa/pKb
11.35 (pKa)

Hazards and Protection.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
Stable under normal shipping and handling conditions.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Health.
Exposure effects
   Ingestion
May cause irritation of the digestive tract. May be harmful if swallowed.
   Inhalation
May cause respiratory tract irritation. May be harmful if inhaled.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin. May cause irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.