Thiamine hydrochloride

  • Vitamin B1 hydrochloride
Formula
C12H17N4OS.ClH.Cl
Structure
Description
White to off-white powder.
Uses
Nutritional supplement.

Registry Numbers and Inventories.
CAS
67-03-8
EC (EINECS/ELINCS)
200-641-8
RTECS
XI7350000
RTECS class
Drug; Human Data
Merck
12,9430
Beilstein/Gmelin
3851771
Beilstein Reference
4-27-00-01764
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C12H17N4OS*ClH*Cl
Formula mass
337.30
Melting point, °C
252
Vapor density (air=1)
10.4
Density
1.401 g/cm3
Solubility in water
1000 g/L

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents.
Decomposition
Hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
100
Autoignition, °C
365
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Health.
Exposure effects
Prolonged or repeated skin contact may cause dermatitis.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Low hazard for usual industrial handling.
   Inhalation
Dust is irritating to the respiratory tract. May cause respiratory tract irritation.
   Skin
May cause skin irritation. May cause dermatitis.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid if irritation or symptoms occur.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.